New Genetic Clues to Breast Cancer? (HealthDay)

SUNDAY, Jan. 22 (HealthDay News) -- Researchers have identified three new genomic regions they believe are linked with breast cancer that may help explain why some women develop the disease.

All three newly identified areas "contain interesting genes that open up new avenues for biological and clinical research," said researcher Douglas Easton, a professor of genetic epidemiology at the University of Cambridge in England.

Breast cancer is the most common cancer among women, with about 1 million new cases annually worldwide and more than 400,000 deaths a year.

Scientists conducting genome-wide association studies -- research that looks at the association between genetic factors and disease to pinpoint possible causes -- had already identified 22 breast cancer susceptibility loci. Locus is the physical location of a gene or DNA sequence on a chromosome.

"The three [newly identified] loci take the number of common susceptibility loci from 22 to 25," said Easton.

However, the three new susceptibility loci might explain only about 0.7 percent of the familial risks of breast cancer, bringing the total contribution to about 9 percent, the researchers said.

Michael Melner, scientific program director for the American Cancer Society, said this current research adds some important new clues to existing evidence, but he agreed that the number of cases likely associated with these three variants is probably low.

"So the total impact in terms of patients would be fairly small," Melner said.

The study is published online Jan. 22 in Nature Genetics.

To find the new clues, Easton's team worked with genetic information on about 57,000 breast cancer patients and 58,000 healthy women obtained from two genome-wide association studies.

The investigators zeroed in on 72 different single nucleotide polymorphisms (SNPs). A SNP -- pronounced "snip" -- is a change in which a single base in the DNA differs from the usual base. The human genome has millions of SNPs, some linked with disease, while others are normal variations.

The researchers focused on three SNPs -- on chromosomes 12p11, 12q24 and 21q21.

Easton's team found that the variant on the 12p11 chromosome is linked with both estrogen receptor-positive breast cancer (which needs estrogen to grow) and estrogen receptor-negative breast cancer. The other two variants are only linked with ER-positive cancers, they said.

One of the newly identified variants is in an area with a gene that has a role in the development of mammary glands and bones. Easton said it was already known that mammary gland development in puberty is an important period in terms of determining later cancer risk. "But these are the first susceptibility genes to be shown to be involved in this process," he said.

One of the other SNPs is in an area that can affect estrogen receptor signaling, the researchers found.

Melner, noting some of the research is "fine tuning" of other work, said in his view the new understanding of the signaling pathways and their genetic links is the most important finding.

"When you delineate a pathway, you bring up new potential targets for therapy," he said. "The more targets you have, you open up the potential for having multiple drugs and attacking a cancer more easily, without it becoming more resistant."

Overall, Melner added, the results underscore the complexity of the different mechanisms involved in breast cancer development.

More information

For more about the genetics of breast cancer, visit the American Cancer Society.

Source: http://us.rd.yahoo.com/dailynews/rss/cancer/*http%3A//news.yahoo.com/s/hsn/20120123/hl_hsn/newgeneticcluestobreastcancer

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Nook Simple Touch gets USB host mode support via hack, plays nice with low-power devices (video)

Codemonkeys exhibiting the kindness of strangers? Why, yes, this is such a tale. When XDA Developers member verygreen came across the pleas of one user obsessed with attaching an external USB keyboard to an eReader, he did what any decent hacker would and created a workable solution. Using a loaned Nook Simple Touch, this self-styled Make-A-Wish Hack was able to patch Barnes & Noble's existing kernel, which already supported USB host mode, and send commands over ADB to enable the connection. It's not a foolproof workaround, though, as only low-power devices will function without additional juice and even so, at a great cost to the greyscale device's battery life. Sure, this may not excite you much, but it's certainly made for one very satisfied forum dweller out there in cyberland. After all, isn't that what haxxors are for?

Continue reading Nook Simple Touch gets USB host mode support via hack, plays nice with low-power devices (video)

Nook Simple Touch gets USB host mode support via hack, plays nice with low-power devices (video) originally appeared on Engadget on Mon, 23 Jan 2012 20:58:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/01/23/nook-simple-touch-gets-usb-host-mode-support-via-hack-plays-nic/

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It's evolution: Nature of prejudice, aggression different for men and women

Public release date: 24-Jan-2012
[ | E-mail | Share ]

Contact: Carlos David Navarrete
cdn@msu.edu
517-432-8391
Michigan State University

EAST LANSING, Mich. Prejudice is linked to aggression for men and fear for women, suggests new research led by Michigan State University scholars.

The researchers report that, throughout history, men have been the primary aggressors against different groups as well as the primary victims of group-based aggression and discrimination.

"There is evidence going back thousands of years of bands of men getting together and attacking other bands of men, eliminating them and keeping the women as the spoils of war," said Carlos David Navarrete, evolutionary psychologist at MSU.

As modern examples, Navarrete noted the wars in Central Africa and the Balkans that were marred by rape and genocide.

Navarrete co-authored the study with MSU researcher Melissa McDonald and Mark Van Vugt of the University of Amsterdam and the University of Oxford. The research appears in Philosophical Transactions of the Royal Society B, a London-based research journal.

The researchers analyzed current academic literature on war and conflict and found that the standard social science theory did not explain the sex differences in aggressive or discriminatory behavior between groups. They offered a novel theory that integrates psychology with ecology and evolutionary biology. Their "male warrior hypothesis" explains how a deep evolutionary history of group conflict may have provided the backdrop for natural selection to shape the social psychologies and behaviors of men and women in fundamentally distinct ways.

Essentially, men are more likely to start wars and to defend their own group, sometimes in very risky and self-sacrificial ways. Attacking other groups represents an opportunity to offset these costs by gaining access to mates, territory, resources and increased status.

The authors complement these findings with results from lab experiments showing that men are more prejudiced toward other groups.

Women, meanwhile, live under the threat of sexual coercion by foreign aggressors, and are apt to display a "tend-and-befriend response" toward members of their own group, while maintaining a fear of strangers in order to protect themselves and their offspring.

"Although these sex-specific responses may have been adaptive in ancestral times," said McDonald, the lead author of the study, "they have likely lost this adaptive value in our modern society, and now act only to needlessly perpetuate discrimination and conflict among groups.

Navarrete added that the behavior is seen in humans' closest relative, the chimpanzee. "Just like humans, they'll attack and kill the males of other groups. They'll also attack females not to the point of killing them, but more to get them to join their group," he said.

Since the behaviors are common among both humans and chimps, they are likely to have existed in our common ancestor millions of years ago, Navarrete said.

"This would have provided eons of time for the deepest workings of our minds to have been fundamentally shaped by these cruel realities," he said. "Coming to grips with this history and how it still affects us in modern times may be an important step into improving the problems caused by our darker predispositions."

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[ | E-mail | Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 24-Jan-2012
[ | E-mail | Share ]

Contact: Carlos David Navarrete
cdn@msu.edu
517-432-8391
Michigan State University

EAST LANSING, Mich. Prejudice is linked to aggression for men and fear for women, suggests new research led by Michigan State University scholars.

The researchers report that, throughout history, men have been the primary aggressors against different groups as well as the primary victims of group-based aggression and discrimination.

"There is evidence going back thousands of years of bands of men getting together and attacking other bands of men, eliminating them and keeping the women as the spoils of war," said Carlos David Navarrete, evolutionary psychologist at MSU.

As modern examples, Navarrete noted the wars in Central Africa and the Balkans that were marred by rape and genocide.

Navarrete co-authored the study with MSU researcher Melissa McDonald and Mark Van Vugt of the University of Amsterdam and the University of Oxford. The research appears in Philosophical Transactions of the Royal Society B, a London-based research journal.

The researchers analyzed current academic literature on war and conflict and found that the standard social science theory did not explain the sex differences in aggressive or discriminatory behavior between groups. They offered a novel theory that integrates psychology with ecology and evolutionary biology. Their "male warrior hypothesis" explains how a deep evolutionary history of group conflict may have provided the backdrop for natural selection to shape the social psychologies and behaviors of men and women in fundamentally distinct ways.

Essentially, men are more likely to start wars and to defend their own group, sometimes in very risky and self-sacrificial ways. Attacking other groups represents an opportunity to offset these costs by gaining access to mates, territory, resources and increased status.

The authors complement these findings with results from lab experiments showing that men are more prejudiced toward other groups.

Women, meanwhile, live under the threat of sexual coercion by foreign aggressors, and are apt to display a "tend-and-befriend response" toward members of their own group, while maintaining a fear of strangers in order to protect themselves and their offspring.

"Although these sex-specific responses may have been adaptive in ancestral times," said McDonald, the lead author of the study, "they have likely lost this adaptive value in our modern society, and now act only to needlessly perpetuate discrimination and conflict among groups.

Navarrete added that the behavior is seen in humans' closest relative, the chimpanzee. "Just like humans, they'll attack and kill the males of other groups. They'll also attack females not to the point of killing them, but more to get them to join their group," he said.

Since the behaviors are common among both humans and chimps, they are likely to have existed in our common ancestor millions of years ago, Navarrete said.

"This would have provided eons of time for the deepest workings of our minds to have been fundamentally shaped by these cruel realities," he said. "Coming to grips with this history and how it still affects us in modern times may be an important step into improving the problems caused by our darker predispositions."

###

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-01/msu-ien012412.php

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Lawmakers ponder major repairs to UK's Parliament

The Palace of Westminster including St Stephen's Tower housing the famous Big Ben clock in London, Monday, Jan. 23, 2012. British lawmakers are considering whether they will need to abandon the House of Commons for the first time since World War II. Legislators were meeting Monday to discuss if future maintenance work to the Palace of Westminster _ home to the Commons and the House of Lords _ would need the two chambers to briefly move out. Consideration of possible repairs follows the disclosure in October that Parliament's clock tower _ often known as Big Ben _ is nearly 18 inches (nearly half a meter) out of line. The palace, which was rebuilt in the mid-19th Century, is expected to need major repairs in the coming years. (AP Photo/Kirsty Wigglesworth)

The Palace of Westminster including St Stephen's Tower housing the famous Big Ben clock in London, Monday, Jan. 23, 2012. British lawmakers are considering whether they will need to abandon the House of Commons for the first time since World War II. Legislators were meeting Monday to discuss if future maintenance work to the Palace of Westminster _ home to the Commons and the House of Lords _ would need the two chambers to briefly move out. Consideration of possible repairs follows the disclosure in October that Parliament's clock tower _ often known as Big Ben _ is nearly 18 inches (nearly half a meter) out of line. The palace, which was rebuilt in the mid-19th Century, is expected to need major repairs in the coming years. (AP Photo/Kirsty Wigglesworth)

LONDON (AP) ? British lawmakers are considering whether they will need to abandon the House of Commons for the first time since World War II.

Legislators were meeting Monday to discuss if future maintenance work to the Palace of Westminster ? home to the Commons and the House of Lords ? would need the two chambers to briefly move out.

Between 1940 and 1941, both Houses of Parliament met in London's Church House, after bombs destroyed the Commons chamber and damaged the Lords.

Consideration of possible repairs follows the disclosure in October that Parliament's clock tower ? known as Big Ben ? is nearly 18 inches (nearly half a meter) out of line.

The palace, which was rebuilt in the mid-19th Century, is expected to need major repairs in the coming years.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-01-23-EU-Britain-Parliament/id-9564fe33bed445e0a57a41d86af8e2a2

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'Voice' sneak peek: Tearjerker of an audition

By Jenna Mullins, E! Online

Art Streiber / NBC

If reality competitions know how to do one thing, it's tug on those heartstrings.

In this exclusive first look at a contestant's blind audition on "The Voice," a single father puts his future in one song, all in hope that one judge turns that giant chair around ...

More from E! Online: Lea Michele headed to 'Glee Project'

Jesse Campbell's story is one straight out of the movies: his wife left him, he ended up homeless and he had to sleep in his car with his little girl on his chest. He found a new life through singing, at weddings and churches, and now in his 40s, he's counting on his voice to bring him and his daughter the future they deserve.

But of course, it's up to judges Adam Levine, Christina Aguilera, Cee Lo Green and Blake Shelton if he makes it to the next round. Do they press the button and swing around? Watch the video below to find out, and then tune in to E! News tonight at 7 for the whole story (TODAY.com, NBC and E! are part of the NBCUniversal family).

"The Voice" premieres Feb. 5, after the Super Bowl, on NBC.

Do you think Jesse can win "The Voice"? Share your thoughts on our Facebook page!

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Source: http://theclicker.today.msnbc.msn.com/_news/2012/01/23/10218343-voice-sneak-peek-tearjerker-of-an-audition

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Five Best Online Meeting Services [Hive Five]

If you work at a company with employees in offices around the globe, or you work in a small company but want to collaborate with a contractor who works from home or vendor across the country, you need a service that will let you connect with your team, share documents, collaborate on them, and in some cases even share your screen or webcam with them. Here are five of the best services to conduct productive online meetings, based on your nominations.

Earlier in the week we asked you which services you used for online meetings. You responded with lots of great options that you use personally or your company provides for you. Here's a look at the top five.

Cisco WebEx ($19/mo - $49/mo)

WebEx is probably one of the oldest and most commonly used online meeting services in the market. WebEx's customer portfolio is impressive, and their online meeting service is incredibly easy to use. Install the WebEx plugin on your desktop that allows you to quickly host or join meetings, and a few clicks will get you working with your team, sharing screens, passing around the "presenter" role to others who have documents to show, or even chatting face-to-face in minutes. WebEx integrates with apps on your desktop so you can schedule an appointment and instantly add a meeting to it, start a meeting and email the attendees quickly, or even join a meeting on your mobile device or tablet. WebEx has a number of products and subscription plans for individuals, small businesses, or large enterprises that offer different features depending on what you need (and what you can afford), but one thing is sure-these features don't come cheap.

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GoToMeeting ($49/mo)

GoToMeeting is another tool used by individuals and enterprises to host online meetings, collaborate on documents, and share desktops and screens among colleagues. The service offers a wealth of enterprise features even to individual users, like desktop sharing, HD video conferencing, and mobile apps that allow you to attend GoToMeeting meetings on your iOS or Android device. Install the GoToMeeting application on your Mac or PC and you can start meetings with a single click, or set them up meticulously so you only share the information you want to with the people you want to invite. Attendees get a tiny plug-in to install before they can join your meetings, but once installed, joining your meetings is a one-click affair.

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Google+ Hangouts (Free)

A number of you mentioned that Google's recent addition of screen sharing and document collaboration to Google+ Hangouts has rocketed it to the top of your list of online meeting services. We can't blame you?it's no secret we love Google+ Hangouts, and the service keeps getting better, with free voice calls and large, clear video. In addition to the ability to see your friends clearly, host a meeting with several of them, share documents via Google Docs and collaborate, you get the benefit of being able to do it all on the web, for free. The only thing you need is a Google account, a webcam, and a microphone.

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TeamViewer (Free)

TeamViewer has a reputation for being a fast and hassle-free method to troubleshoot remote computers, but it's also a great method to get a team together on the web, share screens, chat, and work together on documents. TeamViewer allows you to?for the low price of free?start instant meetings, schedule them in advance and email your attendees when they should join and the access code needed to see your screen, share your screen or pass the "host" role to another meeting attendee so they can share theirs, and even stream video from your webcam to the group so you can all see one another's faces while you talk. TeamViewer also offers mobile apps so you can attend online meetings from your iOS or Android device.

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Join.me (Free, $19/mo Pro)

Also more often considered a remote control and support tool than an online meeting service, Join.me, a free service from the folks at LogMeIn, has the features to pull double duty. The service allows you to bring up to 250 viewers into the same room, share your screen with them, chat, send files around to your attendees, and, like the others, offers iOS and Android apps for remote viewing. If you're willing to spend some coin, the Join.me Pro gets you the ability to make another attendee the presenter so they can share their screen, the ability to pre-schedule and lock meetings, and a desktop app to make meeting management easy.

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Now that you've seen the top five, it's time to put them to an all-out vote.

Honorable mentions this week go to two up and coming meeting services with passionate user-bases, iMeet and MeetingBurner. Both services offer a wealth of features including screen sharing, document collaboration, and multi-person meetings for free for most users. If you've tried the big names above and just haven't really found what you're looking for, or want to try something new, give these guys a shot.

Did your favorite not get enough nominations to make the top five? Know about a feature about one of the contenders we neglected to mention? Share your tips?and your alternative services?in the comments below.

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/LR6EAaqHUA4/five-best-online-meeting-services

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Kathy Griffin Strips For Letterman (Video)

Comedian Kathy Griffin loves shocking people and she did just that when she stripped down to her skivvies for David Letterman on his show last night. It was highly entertaining to say the least and you can see the video clip right here. Griffin was a guest on Dave?s show last night and they began chit chatting about her hosting New Years Eve for CNN with Anderson Cooper. If you watched the NYE special then you know that at one point Kathy just started taking off her clothes until she was only in her undies and a bra of course. Poor Anderson was like WTF as his co-host stood there trying to justify why she pulled such a prank. Anyway so while appearing on Letterman, Dave of course asked her about this little prank that she pulled, so of course being the I don?t give a you know what about what anyone thinks I will do what the heck I want, kind of gal that she is Kathy informs the talk show host that she will take it all off right there. The look on Letterman?s face is priceless, like he was really going to say ?no don?t do that? [...]

Source: http://feedproxy.google.com/~r/RightCelebrity/~3/7-RP6sozpQg/

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